<p> This entry represents what appears to be a phylogenetically distinct clade, containing <taxon tax_id="562">Escherichia coli</taxon> CspD (<db_xref db="SWISSPROT" dbkey="P24245"/>) and related proteobacterial proteins within the larger family of cold shock domain proteins. The gene symbol cspD may have been used independently for other subfamilies of cold shock domain proteins, such as for <taxon tax_id="1423">Bacillus subtilis</taxon> CspD. These proteins typically are shorter than 70 amino acids. In E. coli, CspD is a stress response protein induced in stationary phase. This homodimer binds single-stranded DNA and appears to inhibit DNA replication [<cite idref="PUB00017061"/>]. </p> CspD, cold shock